The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors
Identifieur interne : 000479 ( Main/Exploration ); précédent : 000478; suivant : 000480The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors
Auteurs : Jeffrey N. Savas [États-Unis] ; Luís F. Ribeiro [Belgique] ; Keimpe D. Wierda [Belgique] ; Rebecca Wright [États-Unis] ; Laura A. Denardo [États-Unis] ; Heather C. Rice [Belgique] ; Ingrid Chamma [France] ; Yi-Zhi Wang [États-Unis] ; Roland Zemla [États-Unis] ; Mathieu Lavallée-Adam [États-Unis] ; Kristel M. Vennekens [Belgique] ; Matthew L. O'Sullivan [États-Unis] ; Joseph K. Antonios [États-Unis] ; Elizabeth A. Hall [États-Unis] ; Olivier Thoumine [France] ; Alan D. Attie [États-Unis] ; Anirvan Ghosh [États-Unis, Suisse] ; John R. Yates [États-Unis] ; Joris De Wit [Belgique]Source :
- Neuron [ 0896-6273 ] ; 2015.
Abstract
The formation, function, and plasticity of synapses require dynamic changes in synaptic receptor composition. Here we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking. Four independent proteomic analyses identify the synaptic adhesion molecule neurexin and the AMPA glutamate receptor (AMPAR) as major proteins sorted by SorCS1. SorCS1 localizes to early and recycling endosomes and regulates neurexin and AMPAR surface trafficking. Surface proteome analysis of
Url:
DOI: 10.1016/j.neuron.2015.08.007
PubMed: 26291160
PubMed Central: 4692362
Affiliations:
- Belgique, France, Suisse, États-Unis
- Aquitaine, Californie, Illinois, Nouvelle-Aquitaine, Province du Brabant flamand, Wisconsin
- Bordeaux, Louvain
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Savas</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL 60611, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Ribeiro, Luis F" sort="Ribeiro, Luis F" uniqKey="Ribeiro L" first="Luís F." last="Ribeiro">Luís F. Ribeiro</name><affiliation wicri:level="3"><nlm:aff id="A2">VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Wierda, Keimpe D" sort="Wierda, Keimpe D" uniqKey="Wierda K" first="Keimpe D." last="Wierda">Keimpe D. Wierda</name><affiliation wicri:level="3"><nlm:aff id="A2">VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Wright, Rebecca" sort="Wright, Rebecca" uniqKey="Wright R" first="Rebecca" last="Wright">Rebecca Wright</name><affiliation wicri:level="2"><nlm:aff id="A3">Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Denardo, Laura A" sort="Denardo, Laura A" uniqKey="Denardo L" first="Laura A." last="Denardo">Laura A. Denardo</name><affiliation wicri:level="2"><nlm:aff id="A3">Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rice, Heather C" sort="Rice, Heather C" uniqKey="Rice H" first="Heather C." last="Rice">Heather C. Rice</name><affiliation wicri:level="3"><nlm:aff id="A2">VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Chamma, Ingrid" sort="Chamma, Ingrid" uniqKey="Chamma I" first="Ingrid" last="Chamma">Ingrid Chamma</name><affiliation wicri:level="3"><nlm:aff id="A4">CNRS University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Wang, Yi Zhi" sort="Wang, Yi Zhi" uniqKey="Wang Y" first="Yi-Zhi" last="Wang">Yi-Zhi Wang</name><affiliation wicri:level="2"><nlm:aff id="A5">Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL 60611, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Zemla, Roland" sort="Zemla, Roland" uniqKey="Zemla R" first="Roland" last="Zemla">Roland Zemla</name><affiliation wicri:level="1"><nlm:aff id="A6">New York University School of Medicine, New York, New York 10016, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York University School of Medicine, New York, New York 10016</wicri:regionArea><wicri:noRegion>New York 10016</wicri:noRegion></affiliation></author><author><name sortKey="Lavallee Adam, Mathieu" sort="Lavallee Adam, Mathieu" uniqKey="Lavallee Adam M" first="Mathieu" last="Lavallée-Adam">Mathieu Lavallée-Adam</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Vennekens, Kristel M" sort="Vennekens, Kristel M" uniqKey="Vennekens K" first="Kristel M." last="Vennekens">Kristel M. Vennekens</name><affiliation wicri:level="3"><nlm:aff id="A2">VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="O Sullivan, Matthew L" sort="O Sullivan, Matthew L" uniqKey="O Sullivan M" first="Matthew L." last="O'Sullivan">Matthew L. O'Sullivan</name><affiliation wicri:level="2"><nlm:aff id="A3">Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Antonios, Joseph K" sort="Antonios, Joseph K" uniqKey="Antonios J" first="Joseph K." last="Antonios">Joseph K. Antonios</name><affiliation wicri:level="2"><nlm:aff id="A3">Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hall, Elizabeth A" sort="Hall, Elizabeth A" uniqKey="Hall E" first="Elizabeth A." last="Hall">Elizabeth A. Hall</name><affiliation wicri:level="2"><nlm:aff id="A5">Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL 60611, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Thoumine, Olivier" sort="Thoumine, Olivier" uniqKey="Thoumine O" first="Olivier" last="Thoumine">Olivier Thoumine</name><affiliation wicri:level="3"><nlm:aff id="A4">CNRS University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Attie, Alan D" sort="Attie, Alan D" uniqKey="Attie A" first="Alan D." last="Attie">Alan D. Attie</name><affiliation wicri:level="2"><nlm:aff id="A7">Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Wisconsin, Madison, WI 53706</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Ghosh, Anirvan" sort="Ghosh, Anirvan" uniqKey="Ghosh A" first="Anirvan" last="Ghosh">Anirvan Ghosh</name><affiliation wicri:level="2"><nlm:aff id="A3">Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Neuroscience Discovery, F. Hoffman-La Roche, 4070 Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Neuroscience Discovery, F. Hoffman-La Roche, 4070 Basel</wicri:regionArea><wicri:noRegion>4070 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Yates, John R" sort="Yates, John R" uniqKey="Yates J" first="John R." last="Yates">John R. Yates</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="De Wit, Joris" sort="De Wit, Joris" uniqKey="De Wit J" first="Joris" last="De Wit">Joris De Wit</name><affiliation wicri:level="3"><nlm:aff id="A2">VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>VIB Center for the Biology of Disease, 3000 Leuven, Belgium; KU Leuven, Center for Human Genetics, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author></analytic><series><title level="j">Neuron</title><idno type="ISSN">0896-6273</idno><idno type="eISSN">1097-4199</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The formation, function, and plasticity of synapses require dynamic changes in synaptic receptor composition. Here we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking. Four independent proteomic analyses identify the synaptic adhesion molecule neurexin and the AMPA glutamate receptor (AMPAR) as major proteins sorted by SorCS1. SorCS1 localizes to early and recycling endosomes and regulates neurexin and AMPAR surface trafficking. Surface proteome analysis of <italic>SorCS1</italic>-deficient neurons shows decreased surface levels of these, and additional, receptors. Quantitative in vivo analysis of <italic>SorCS1</italic> knockout synaptic proteomes identifies SorCS1 as a global trafficking regulator and reveals decreased levels of receptors regulating adhesion and neurotransmission, including neurexins and AMPARs. Consequently, glutamatergic transmission at <italic>SorCS1</italic>–deficient synapses is reduced due to impaired AMPAR surface expression. <italic>SORCS1</italic> mutations have been associated with autism and Alzheimer's disease, suggesting that perturbed receptor trafficking contributes to defects in synaptic composition and function underlying synaptopathies.</p></div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li><li>Suisse</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Californie</li><li>Illinois</li><li>Nouvelle-Aquitaine</li><li>Province du Brabant flamand</li><li>Wisconsin</li></region><settlement><li>Bordeaux</li><li>Louvain</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Savas, Jeffrey N" sort="Savas, Jeffrey N" uniqKey="Savas J" first="Jeffrey N." last="Savas">Jeffrey N. Savas</name></region><name sortKey="Antonios, Joseph K" sort="Antonios, Joseph K" uniqKey="Antonios J" first="Joseph K." last="Antonios">Joseph K. Antonios</name><name sortKey="Attie, Alan D" sort="Attie, Alan D" uniqKey="Attie A" first="Alan D." last="Attie">Alan D. Attie</name><name sortKey="Denardo, Laura A" sort="Denardo, Laura A" uniqKey="Denardo L" first="Laura A." last="Denardo">Laura A. Denardo</name><name sortKey="Ghosh, Anirvan" sort="Ghosh, Anirvan" uniqKey="Ghosh A" first="Anirvan" last="Ghosh">Anirvan Ghosh</name><name sortKey="Hall, Elizabeth A" sort="Hall, Elizabeth A" uniqKey="Hall E" first="Elizabeth A." last="Hall">Elizabeth A. Hall</name><name sortKey="Lavallee Adam, Mathieu" sort="Lavallee Adam, Mathieu" uniqKey="Lavallee Adam M" first="Mathieu" last="Lavallée-Adam">Mathieu Lavallée-Adam</name><name sortKey="O Sullivan, Matthew L" sort="O Sullivan, Matthew L" uniqKey="O Sullivan M" first="Matthew L." last="O'Sullivan">Matthew L. O'Sullivan</name><name sortKey="Savas, Jeffrey N" sort="Savas, Jeffrey N" uniqKey="Savas J" first="Jeffrey N." last="Savas">Jeffrey N. Savas</name><name sortKey="Wang, Yi Zhi" sort="Wang, Yi Zhi" uniqKey="Wang Y" first="Yi-Zhi" last="Wang">Yi-Zhi Wang</name><name sortKey="Wright, Rebecca" sort="Wright, Rebecca" uniqKey="Wright R" first="Rebecca" last="Wright">Rebecca Wright</name><name sortKey="Yates, John R" sort="Yates, John R" uniqKey="Yates J" first="John R." last="Yates">John R. Yates</name><name sortKey="Zemla, Roland" sort="Zemla, Roland" uniqKey="Zemla R" first="Roland" last="Zemla">Roland Zemla</name></country><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Ribeiro, Luis F" sort="Ribeiro, Luis F" uniqKey="Ribeiro L" first="Luís F." last="Ribeiro">Luís F. Ribeiro</name></region><name sortKey="De Wit, Joris" sort="De Wit, Joris" uniqKey="De Wit J" first="Joris" last="De Wit">Joris De Wit</name><name sortKey="Rice, Heather C" sort="Rice, Heather C" uniqKey="Rice H" first="Heather C." last="Rice">Heather C. Rice</name><name sortKey="Vennekens, Kristel M" sort="Vennekens, Kristel M" uniqKey="Vennekens K" first="Kristel M." last="Vennekens">Kristel M. Vennekens</name><name sortKey="Wierda, Keimpe D" sort="Wierda, Keimpe D" uniqKey="Wierda K" first="Keimpe D." last="Wierda">Keimpe D. Wierda</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Chamma, Ingrid" sort="Chamma, Ingrid" uniqKey="Chamma I" first="Ingrid" last="Chamma">Ingrid Chamma</name></region><name sortKey="Thoumine, Olivier" sort="Thoumine, Olivier" uniqKey="Thoumine O" first="Olivier" last="Thoumine">Olivier Thoumine</name></country><country name="Suisse"><noRegion><name sortKey="Ghosh, Anirvan" sort="Ghosh, Anirvan" uniqKey="Ghosh A" first="Anirvan" last="Ghosh">Anirvan Ghosh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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